Pharmacology

Olanzapine is similar structurally in clozapine, but classified as a thienobenzodiazepine. Olanzapine has a higher affinity as receivers serotonin 5-HT2 that D2 dopamine receivers.

As most atypical antipsychotics, compared with the older typical, olanzapine has a lower affinity as the histamine, cholinergic muscarinic receivers and adrénergiques alpha. He also has a weak affinity as receivers benzodiazepine who can contribute slightly to its mettantes properties under sedatives. The mode of action of the antipsychotic activity of olanzapine is unknown. He can implicate antagonism in receivers serotonin. The antagonism of receivers dopamine is linked to the effects of extrapyramidal such as late dyskinesia and with therapeutic effects. The fact of Contrarier of receivers histaminiques of H1 causes sedation and can cause weighty benefit, although actions compared to receivers 5-HT2C are also involved in weighty benefit.